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KMID : 0043319940170020119
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Archives of Pharmacal Research
1994 Volume.17 No. 2 p.119 ~ p.123
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Synthesis of Antithypertensive Agents via Couping Reaction of Benzothiazepinone and 1,4-Dihydropyridine Derivatives
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Ham Won-Hun
Yang Jae-Gwon
Lim Tae-Gyun
Jung Yun-Ho
Chung Yun-Sung
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Abstract
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The synthesis of 3a, 3b, 7a fro Benzpthiazepinone and 1,4-dihyropyridine derivatives is described. Benzothiazepinone nad 1,4-dihydropyridine derivatives were prepared according to literature procedure. The key reactions involve esterification and amidation of benzothize-pinone nad 1,4-dihydropyridine derivatives.
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KEYWORD
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Antihypertensive agents, Calcium channel blocker, Benzothiazepinone, 1, 4-dihyd-ropyridine
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